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Laurel A. Beckett, PhD
Professor

Biostatistics Unit
Department of Public Health Sciences
Med Sci 1-C
University of California
Davis, California 95616

Research Interests:

Statistical methods for longitudinal data, population-based studies, and translational research between basic science and clinical medicine. Collaborative research using these methods for studies of chronic diseases, especially the relationship between biology, etiology, and treatment. Current and recent research includes work on Alzheimer's, AIDS, cancer, hypertension, and pulmonary disease.

SELECTED JOURNAL ARTICLES

Henn, Jennifer B, Chu-Hao Liu, Rick W Kasten, Brian A VanHorn, Laurel A Beckett, Philip H Kass and Bruno B Chomel (2005) Seroprevalence of antibodies against Bartonella species and evaluation of risk factors and clinical signs associated with seropositivity in dogs. Am J Vet Res. 66(4):688-94.

Pan XL, HW Day, W Wang, LA Beckett and MB Schenker (2005) Residential Proximity to Naturally Occurring Asbestos and Mesothelioma Risk in California. Am J Respir Crit Care Med. .

Beckett, L A, D J Tancredi and R S Wilson (2004) Multivariate longitudinal models for complex change processes. Stat Med. 23(2):231-9.

Danhauer, Suzanne C, Judith J McCann, David W Gilley, Laurel A Beckett, Julia L Bienias and Denis A Evans (2004) Do behavioral disturbances in persons with Alzheimer's disease predict caregiver depression over time?. Psychol Aging. 19(1):198-202.

deVere White, Ralph W, Robert M Hackman, Stephanie E Soares, Laurel A Beckett, Yueju Li and Buxiang Sun (2004) Effects of a genistein-rich extract on PSA levels in men with a history of prostate cancer. Urology. 63(2):259-63.

McCann, Judith J, David W Gilley, Julia L Bienias, Laurel A Beckett and Denis A Evans (2004) Temporal patterns of negative and positive behavior among nursing home residents with Alzheimer's disease. Psychol Aging. 19(2):336-45.

Murray, Anne M, David A Bennett, Carlos F Mendes de Leon, Laurel A Beckett and Denis A Evans (2004) A longitudinal study of parkinsonism and disability in a community population of older people. J Gerontol A Biol Sci Med Sci. 59(8):864-70.

Packianathan, S, Rajendra G Mehta, Rajeshwari R Mehta, William H Hall, Philip S Boerner, Laurel A Beckett and Srinivasan Vijayakumar (2004) Designing a randomized phase I/II prostate cancer chemoprevention trial using 1alpha-hydroxy-24-ethyl-cholecalciferol, an analogue of vitamin D3. Cancer J. 10(6):357-67.

Schenker, Marc B, Maria Stoecklin, Kiyoung Lee, Rafael Lupercio, R Jorge Zeballos, Paul Enright, Tamara Hennessy and Laurel A Beckett (2004) Pulmonary function and exercise-associated changes with chronic low-level paraquat exposure. Am J Respir Crit Care Med. 170(7):773-9.

Shi, Xu-Bao, Regina Gandour-Edwards, Laurel A Beckett, Arline D Deitch and Ralph W de Vere White (2004) A modified yeast assay used on archival samples of localized prostate cancer tissue improves the detection of p53 abnormalities and increases their predictive value. BJU Int. 94(7):996-1002.

Bienias, Julia L, Laurel A Beckett, David A Bennett, Robert S Wilson and Denis A Evans (2003) Design of the Chicago Health and Aging Project (CHAP). J Alzheimers Dis. 5(5):349-55.

Evans, Denis A, David A Bennett, Robert S Wilson, Julia L Bienias, Martha Clare Morris, Paul A Scherr, Liesi E Hebert, Neelum Aggarwal, Laurel A Beckett, Rajiv Joglekar, Elizabeth Berry-Kravis and Julie Schneider (2003) Incidence of Alzheimer disease in a biracial urban community: relation to apolipoprotein E allele status. Arch Neurol. 60(2):185-9.

Harvey, Danielle J, Laurel A Beckett and Dan M Mungas (2003) Multivariate modeling of two associated cognitive outcomes in a longitudinal study. J Alzheimers Dis. 5(5):357-65.

Wilson RS, LA Beckett, JL Bienias, DA Evans and DA Bennett (2003) Terminal decline in cognitive function. Neurology. 60(11):1782-1787.

Bennett, D A, R S Wilson, J A Schneider, D A Evans, L A Beckett, N T Aggarwal, L L Barnes, J H Fox and J Bach (2002) Natural history of mild cognitive impairment in older persons. Neurology. 59(2):198-205.

deVere White, Ralph W, Robert M Hackman, Stephanie E Soares, Laurel A Beckett and Buxiang Sun (2002) Effects of a mushroom mycelium extract on the treatment of prostate cancer. Urology. 60(4):640-4.

Wilson, R S, J A Schneider, L A Beckett, D A Evans and D A Bennett (2002) Progression of gait disorder and rigidity and risk of death in older persons. Neurology. 58(12):1815-9.

Wilson, Robert S, Julie A Schneider, Lisa L Barnes, Laurel A Beckett, Neelum T Aggarwal, Elizabeth J Cochran, Elizabeth Berry-Kravis, Julie Bach, Jacob H Fox, Denis A Evans and David A Bennett (2002) The apolipoprotein E epsilon 4 allele and decline in different cognitive systems during a 6-year period. Arch Neurol. 59(7):1154-60.

Wilson, Robert S, L L Barnes, C F Mendes de Leon, N T Aggarwal, J S Schneider, J Bach, J Pilat, L A Beckett, S E Arnold, D A Evans and D A Bennett (2002) Depressive symptoms, cognitive decline, and risk of AD in older persons. Neurology. 59(3):364-70.

Wilson, Robert S, Laurel A Beckett, Lisa L Barnes, Julie A Schneider, Julie Bach, Denis A Evans and David A Bennett (2002) Individual differences in rates of change in cognitive abilities of older persons. Psychol Aging. 17(2):179-93.

Dickerson, B C, I Goncharova, M P Sullivan, C Forchetti, R S Wilson, D A Bennett, L A Beckett and L deToledo-Morrell (2001) MRI-derived entorhinal and hippocampal atrophy in incipient and very mild Alzheimer's disease. Neurobiol Aging. 22(5):747-54.

Ghoshal, N, F Garcia-Sierra, Y Fu, L A Beckett, E J Mufson, J Kuret, R W Berry and L I Binder (2001) Tau-66: evidence for a novel tau conformation in Alzheimer's disease. J Neurochem. 77(5):1372-85.

Gulsvik, A, LA Beckett, P Bakke, S Humerfelt, E Omenaas and FE Speizer (2001) Standardized submaximal exercise testing in never smokers: a normative study. Clin. Physiol.. 21(5):629-636.

Hebert, L E, P A Scherr, J J McCann, L A Beckett and D A Evans (2001) Is the risk of developing Alzheimer's disease greater for women than for men?. Am J Epidemiol. 153(2):132-6.

Hebert, LE, LA Beckett, PA Scherr and DA Evans (2001) Annual incidence of Alzheimer disease in the United States projected to the years 2000 through 2050. Alzheimer Dis. Assoc. Dis.. 15(4):169-173.

Beckett, LA (2000) Community-based studies of Alzheimer's disease: statistical challenges in design and analysis. Stat. Med.. 19(11-12):1469-1480.

Beckett, LA and DJ Tancredi (2000) Parametric empirical Bayes estimates of disease prevalence using stratifed samples from community populations. Stat. Med.. 19(5):681-695.

Cronin-Stubbs, D, CFM De Leon, LA Beckett, TS Field, RJ Glynn and DA Evans (2000) Six-year effect of depressive symptoms on the course of physical disability in community-living older adults. Arch. Intern. Med.. 160(20):3074-3080.

Hebert, LE, RS Wilson, DW Gilley, LA Beckett, PA Scherr, DA Bennett and DA Evans (2000) Decline of language among women and men with Alzheimer's disease. J. Gerontol. Ser. B-Psychol. Sci. Soc. Sci.. 55(6):P354-P360.

McCann, JJ, LE Hebert, LA Beckett, MC Morris, PA Scherr and DA Evans (2000) Comparison of informal caregiving by black and white older adults in a community population. J. Am. Geriatr. Soc.. 48(12):1612-1617.

Wilson, RS, D W Gilley, D A Bennett, L A Beckett and D A Evans (2000) Person-specific paths of cognitive decline in Alzheimer's disease and their relation to age. Psychol Aging. 15(1):18-28.

Wilson, RS, DA Bennett, DW Gilley, LA Beckett, JA Schneider and DA Evans (2000) Progression of parkinsonism and loss of cognitive function in Alzheimer disease. Arch. Neurol.. 57(6):855-860.

Wilson, RS, DA Bennett, DW Gilley, LA Beckett, LL Barnes and DA Evans (2000) Premorbid reading activity and patterns of cognitive decline in Alzheimer disease. Arch. Neurol.. 57(12):1718-1723.

Wilson, RS, DW Gilley, DA Bennett, LA Beckett and DA Evans (2000) Hallucinations, delusions, and cognitive decline in Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry. 69(2):172-177.

Bennett, DA, KM Shannon, LA Beckett and RS Wilson (1999) Dimensionality of parkinsonian signs in aging and Alzheimer's disease. J. Gerontol. Ser. A-Biol. Sci. Med. Sci.. 54(4):M191-M196.

De Leon, CFM, TA Glass, LA Beckett, TE Seeman, DA Evans and LF Berkman (1999) Social networks and disability transitions across eight intervals of yearly data in the New Haven EPESE. J. Gerontol. Ser. B-Psychol. Sci. Soc. Sci.. 54(3):S162-S172.

Glynn, RJ, LA Beckett, LE Hebert, MC Morris, PA Scherr and DA Evans (1999) Current and remote blood pressure and cognitive decline. JAMA-J. Am. Med. Assoc.. 281(5):438-445.

Mufson, EJ, EY Chen, EJ Cochran, LA Beckett, DA Bennett and JH Kordower (1999) Entorhinal cortex beta-amyloid load in individuals with mild cognitive impairment. Exp. Neurol.. 158(2):469-490.

Wilson, RS, DA Bennett, LA Beckett, MC Morris, DW Gilley, JL Bienias, PA Scherr and DA Evans (1999) Cognitive activity in older persons from a geographically defined population. J. Gerontol. Ser. B-Psychol. Sci. Soc. Sci.. 54(3):P155-P160.

Wilson, RS, LA Beckett, DA Bennett, MS Albert and DA Evans (1999) Change in cognitive function in older persons from a community population - Relation to age and Alzheimer disease. Arch. Neurol.. 56(10):1274-1279.

Morris, MC, LA Beckett, PA Scherr, LE Hebert, DA Bennett, TS Field and DA Evans (1998) Vitamin E and vitamin C supplement use and risk of incident Alzheimer disease. Alzheimer Dis. Assoc. Dis.. 12(3):121-126.

Bennett, DA, KM Shannon, LA Beckett, CG Goetz and RS Wilson (1997) Metric properties of nurses' ratings of parkinsonian signs with a modified Unified Parkinson's Disease Rating Scale. Neurology. 49(6):1580-1587.

Deleon, CFM, LA Beckett, GG Fillenbaum, DB Brock, LG Branch, DA Evans and LF Berkman (1997) Black-white differences in risk of becoming disabled and recovering from disability in old age: A longitudinal analysis Of two Epese Populations. Am. J. Epidemiol.. 145(6):488-497.

Evans, DA, LA Beckett, TS Field, L Feng, MS Albert, DA Bennett, B Tycko and R Mayeux (1997) Apolipoprotein E epsilon 4 and incidence of Alzheimer disease In a Community Population of Older Persons. JAMA-J. Am. Med. Assoc.. 277(10):822-824.

Evans, DA, LE Hebert, LA Beckett, PA Scherr, MS Albert, MJ Chown, DM Pilgrim and JO Taylor (1997) Education and other measures of socioeconomic status and risk Of Incident Alzheimer Disease in a Defined Population of Older persons. Arch. Neurol.. 54(11):1399-1405.

Gilley, DW, RS Wilson, LA Beckett and DA Evans (1997) Psychotic symptoms and physically aggressive behavior in Alzheimer's disease. J. Am. Geriatr. Soc.. 45(9):1074-1079.

McCann, JJ, DW Gilley, LE Hebert, LA Beckett and DA Evans (1997) Concordance between direct observation and staff rating of behavior in nursing home residents with Alzheimer's disease. J. Gerontol. Ser. B-Psychol. Sci. Soc. Sci.. 52(2):P63-P72.

Beckett, LA, DB Brock, JH Lemke, CFM Deleon, JM Guralnik, GG Fillenbaum, LG Branch, TT Wetle and DA Evans (1996) Analysis of change in self-reported physical function among older persons in four population studies. Am. J. Epidemiol.. 143(8):766-778.

Bennett, DA, LA Beckett, AM Murray, KM Shannon, CG Goetz, DM Pilgrim and DA Evans (1996) Prevalence of Parkinsonian signs and associated mortality in a community population of older people. N. Engl. J. Med.. 334(2):71-76.

Deleon, CFM, GG Fillenbaum, CS Williams, DB Brock, LA Beckett and LF Berkman (1995) Functional Disability Among Elderly Blacks and Whites in 2 Diverse Areas - the New-haven and North-carolina Epese. Am. J. Public Health. 85(7):994-998.

Fortin, PR, RA Lew, MH Liang, EA Wright, LA Beckett, TC Chalmers and RI Sperling (1995) Validation of a Metaanalysis - the Effects of Fish-oil in Rheumatoid-arthritis. J. Clin. Epidemiol.. 48(11):1379-1390.

Hebert, LE, PA Scherr, LA Beckett, MS Albert, DM Pilgrim, MJ Chown, HH Funkenstein and DA Evans (1995) Age-specific Incidence of Alzheimers-disease in a Community Population. JAMA-J. Am. Med. Assoc.. 273(17):1354-1359.

Degruttola, V, LA Beckett, RW Coombs, JM Arduino, HH Balfour, S Rasheed, FB Hollinger, MA Fischl, P Volberding and Tact Group (1994) Serum p24 Antigen Level as an Intermediate End-point in Clinical-trials of Zidovudine in People Infected With Human- Immunodeficiency-virus Type-1. J. Infect. Dis.. 169(4):713-721.

Mayers, DL, AJ Japour, JM Arduino, SM Hammer, R Reichman, KF Wagner, R Chung, J Lane, CS Crumpacker, GX Mcleod, LA Beckett, CR Roberts, D Winslow, D Burke, N Ruiz, M Fujimarajustice, P Kernozek, J Koch, C Brewer, C Hicks, ME Shellie, L Lorizlim, C Smalls, A Hamilton, F McCutchan, E Sandersbuell, O Weislow, A Fowler, J Lane and L Merritt (1994) Dideoxynucleoside Resistance Emerges With Prolonged Zidovudine Monotherapy. Antimicrob. Agents Chemother.. 38(2):307-314.

Resnick, NM, LA Beckett, LG Branch, PA Scherr and T Wetle (1994) Short-term Variability of Self-report of Incontinence in Older Persons. J. Am. Geriatr. Soc.. 42(2):202-207.

Dezube, BJ, AB Pardee, B Chapman, LA Beckett, JA Korvick, WJ Novick, J Chiurco, P Kasdan, CM Ahlers, LT Ecto and CS Crumpacker (1993) Pentoxifylline Decreases Tumor-necrosis-factor Expression and Serum Triglycerides in People With Aids. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol.. 6(7):787-794.

Hebert, LE, PA Scherr, LA Beckett, MS Albert, B Rosner, JO Taylor and DA Evans (1993) Relation of Smoking and Low-to-moderate Alcohol-consumption to Change in Cognitive Function - a Longitudinal-study in a Defined Community of Older Persons. Am. J. Epidemiol.. 137(8):881-891.

Japour, AJ, DL Mayers, VA Johnson, DR Kuritzkes, LA Beckett, JM Arduino, J Lane, RJ Black, PS Reichelderfer, RT Daquila, CS Crumpacker, H Balfour, A Erice, R Coombs, D Katzenstein, J Lathey, D Richman, K Mcintosh, S Rangan, R Reichman, W Scott, M Ussery, L Abrams, F McCutchan, D Burke, L Gardner, C Roberts, R Chung, C Hicks, E Shellie, A Fowler, L Merritt, M Fujimurajustice, N Ruiz, K Wagner and M Gail (1993) Standardized Peripheral-blood Mononuclear Cell-culture Assay For Determination of Drug Susceptibilities of Clinical Human- Immunodeficiency-virus Type-1 Isolates. Antimicrob. Agents Chemother.. 37(5):1095-1101.

Austin, JK, MW Risinger and LA Beckett (1992) Correlates of Behavior Problems in Children With Epilepsy. Epilepsia. 33(6):1115-1122.

Beckett, LA, B Rosner, AF Roche and S Guo (1992) Serial Changes in Blood-pressure From Adolescence Into Adulthood. Am. J. Epidemiol.. 135(10):1166-1177.

Beckett, LA, PA Scherr and DA Evans (1992) Population Prevalence Estimates From Complex Samples. J. Clin. Epidemiol.. 45(4):393-402.

Dezube, BJ, AB Pardee, LA Beckett, CM Ahlers, L Ecto, J Allenryan, A Anisowicz, R Sager and CS Crumpacker (1992) Cytokine Dysregulation in Aids - Invivo Overexpression of Messenger-rna of Tumor-necrosis-factor-alpha and its Correlation With That of the Inflammatory Cytokine gro. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol.. 5(11):1099-1104.

Gillman, MW, NR Cook, B Rosner, LA Beckett, DA Evans, ME Keough, JO Taylor and CH Hennekens (1992) Childhood Blood-pressure Tracking Correlations Corrected for Within-person Variability. Stat. Med.. 11(9):1187-1194.

Hebert, LE, PA Scherr, LA Beckett, HH Funkenstein, MS Albert, MJ Chown and DA Evans (1992) Relation of Smoking and Alcohol-consumption to Incident Alzheimers-disease. Am. J. Epidemiol.. 135(4):347-355.

Carpen, O, ML Dustin, TA Springer, JA Swafford, LA Beckett and JP Caulfield (1991) Motility and Ultrastructure of Large Granular Lymphocytes on Lipid Bilayers Reconstituted With Adhesion Receptors LFA-1, ICAM-1, and 2 Isoforms of LFA-3. J. Cell Biol.. 115(3):861-871.

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