Decline of language among women and men with Alzheimer's disease

Hebert, LE, RS Wilson, DW Gilley, LA Beckett, PA Scherr, DA Bennett and DA Evans

J. Gerontol. Ser. B-Psychol. Sci. Soc. Sci.. 2000. 55(6):P354-P360.

Previous research raises the possibility that gender differences occur in language function in Alzheimer's disease, but this hypothesis has not been evaluated systematically in longitudinal studies. The authors examined the association of gender with rate of decline in language and other cognitive functions among 410 persons with Alzheimer's disease. Participants were recruited from a dementia clinic and followed for up to 5 annual evaluations. Follow-up participation among survivors exceeded 90%. Decline in a composite score based on 8 language tests was evaluated in random effects models with age, education, and race controlled, Annual decline was 0.71 standard units (95% confidence interval [CI] = 0.62-0.79) for women and 0.74 units (95% CI = 0.61-0.86) for men, not a significant difference. Decline on the individual language tests and on composite measures of memory, perception, and global cognition also indicated no significant association with gender, These results suggest that Alzheimer's disease affects language and other cognitive functions similarly in women and men.

Keywords: Alzheimer's disease; incidence; mortality; prevalence; prospective studies; risk factors; sex factors; women, Community Population; Japanese Population; Elderly Community; Senile Dementia; Older Persons; Prevalence; Age; Subtypes; Project; Predictors, Leisure Activities; Prose Recall; Education; Dementia; Reserve; Association; Occupation; Diagnosis; Risk; Work, Extrapyramidal Signs; Longitudinal Data; Predictors; Progression; Diagnosis; Dementia; Models; State

Close Window

UC Davis Health System is pleased to provide this information for general reference purposes only. It should not be considered as a substitute for professional medical advice. You are urged to consult with your health care provider for diagnosis of and treatment for any health-related condition. The information provided herein may not and should not be used for diagnosis and treatment.

Reproduction of material on this web site is hereby granted solely for personal use. No other use of this material is authorized without prior written approval of UC Regents.