Community-based studies of Alzheimer's disease: statistical challenges in design and analysis

Beckett, LA

Stat. Med.. 2000. 19(11-12):1469-1480.

Alzheimer's disease is a chronic disease, primarily of the elderly, characterized by progressive dementia and eventual death. Community-based studies will likely provide a better representation of the spectrum of disease than will studies drawn solely from clinical sources, because an unknown and possibly substantial fraction of the cases do not come to the attention of the medical care system, or are diagnosed only very late in the disease. Community-based studies will provide not only more accurate estimates of prevalence and incidence, but also more directly comparable unaffected people for studies of risk factors for onset and progression. Such studies are likely to consist of a census component where relatively inexpensive but useful auxiliary information is collected and a probability sample from the census, with the detailed and costly clinical diagnosis of Alzheimer's disease restricted to the sample. The statistician faces challenges both in designing a sample that meets multiple objectives efficiently and in analysing data from the resulting complex survey designs. Copyright (C) 2000 John Wiley & Sons, Ltd.

Keywords: Alzheimer's disease; hallucinations; cognitive decline, Mini-mental-state; Extrapyramidal Signs; Psychiatric Phenomena; Parkinsonian Signs; Psychotic Symptoms; Functional Decline; Predictors; Progression; Depression; Disorders, Population; Prevalence; Samples

Close Window

UC Davis Health System is pleased to provide this information for general reference purposes only. It should not be considered as a substitute for professional medical advice. You are urged to consult with your health care provider for diagnosis of and treatment for any health-related condition. The information provided herein may not and should not be used for diagnosis and treatment.

Reproduction of material on this web site is hereby granted solely for personal use. No other use of this material is authorized without prior written approval of UC Regents.