Age-specific Incidence of Alzheimers-disease in a Community Population

Hebert, LE, PA Scherr, LA Beckett, MS Albert, DM Pilgrim, MJ Chown, HH Funkenstein and DA Evans

JAMA-J. Am. Med. Assoc.. 1995. 273(17):1354-1359.

Objective.-To determine age-specific incidence rates of clinically diagnosed Alzheimer's disease. Design.-Cohort, followed a mean of 4.3 years. Setting.-East Boston, Mass. Participants.-Of 2313 persons aged 65 years and older who were initially free of Alzheimer's disease, 1601 participated in the ascertainment of incident disease (80% of survivors), 409 declined participation, and 303 died before the end of the follow-up period. A stratified sample of 642 persons received detailed clinical evaluation. Outcome Measure.-Diagnosis of new probable Alzheimer's disease through structured clinical evaluation including neurologic, neuropsychological, and psychiatric examination. Community incidence rates were computed by 5-year age groups, adjusted for gender, single year of age, length of follow-up interval, and sampling design. Results.-The estimated annual incidence of Alzheimer's disease in the population was 0.6% (95% confidence interval [CI], 0.3% to 0.9%) for persons aged 65 to 69 years, 1.0% (95% CI, 0.6% to 1.4%) for persons aged 70 to 74 years, 2.0% (95% CI, 1.3% to 2.7%) for persons aged 75 to 79 years, 3.3% (95% CI, 2.2% to 4.4%) for persons aged 80 to 84 years, and 8.4% (95% CI, 3.7% to 13.1%) for persons aged 85 years and older. Conclusions.-The incidence of Alzheimer's disease is substantial and is approximately 14 times higher among persons older than 85 years compared with those between 65 and 69 years of age.

Keywords: Metaanalysis; Mega-analysis; Technology Assessment; Fish Oil; Eicosapentaenoic Acid; Rheumatoid Arthritis, Polyunsaturated Fatty-acids; Acute Myocardial-infarction; Dietary Supplementation; Clinical-trials; Docosahexaenoic Acids; Generation; Publication; Quality, Alameda County; Health; Life; Predictors; Mortality; Cohort, Dementing Illnesses; Senile Dementia; United-states; Prevalence; Periods; Lundby; Rates



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