Pentoxifylline Decreases Tumor-necrosis-factor Expression and Serum Triglycerides in People With Aids

Dezube, BJ, AB Pardee, B Chapman, LA Beckett, JA Korvick, WJ Novick, J Chiurco, P Kasdan, CM Ahlers, LT Ecto and CS Crumpacker

J. Acquir. Immune Defic. Syndr. Hum. Retrovirol.. 1993. 6(7):787-794.

Tumor necrosis factor-alpha (TNF)-cachectin increases the expression of the human immunodeficiency virus (HIV), reverses the therapeutic efficacy of zidovudine (ZDV), and may contribute to the wasting syndrome. Pentoxifylline (Trental) decreases TNF activity; in cell culture, it decreases HIV replication and down-regulates expression of the HIV long terminal repeat (LTR). Therefore, pentoxifylline was administered to 25 patients with advanced AIDS in this AIDS Clinical Trial Group study (ACTG # 160), the goal of which was to investigate the ability of the drug to decrease TNF expression and HIV replication in this patient population. One patient discontinued drug treatment because of toxicity. Data were analyzed on the 17 patients who completed the 8-week study treatment with pentoxifylline, 400 mg, thrice daily. The median pretreatment CD4+ lymphocyte count was 32 cells/mm3. Fasting serum triglycerides, which have previously been shown to correlate with levels of interferon-alpha and/or TNF, fell on average by 66 mg/dl (p = 0.06). TNF mRNA levels in peripheral blood mononuclear cells fell in 10 of 16 patients (p = 0.02). HIV load decreased and increased significantly in four and one patients, respectively, but did not change in the group as a whole. This study demonstrates the safety of pentoxifylline in AIDS patients and its ability to decrease triglycerides and TNF mRNA levels.

Keywords: Hiv; Tumor Necrosis Factor; Pentoxifylline; Cytokines; Triglycerides, Immunodeficiency-virus Type-1; Bone-marrow Transplantation; Blood Mononuclear-cells; Factor-alpha; Cancer-patients; t- Cells; Cachectin; Induction; Hypertriglyceridemia; Replication

Close Window

UC Davis Health System is pleased to provide this information for general reference purposes only. It should not be considered as a substitute for professional medical advice. You are urged to consult with your health care provider for diagnosis of and treatment for any health-related condition. The information provided herein may not and should not be used for diagnosis and treatment.

Reproduction of material on this web site is hereby granted solely for personal use. No other use of this material is authorized without prior written approval of UC Regents.