Cytokine Dysregulation in Aids - Invivo Overexpression of Messenger-rna of Tumor-necrosis-factor-alpha and its Correlation With That of the Inflammatory Cytokine gro

Dezube, BJ, AB Pardee, LA Beckett, CM Ahlers, L Ecto, J Allenryan, A Anisowicz, R Sager and CS Crumpacker

J. Acquir. Immune Defic. Syndr. Hum. Retrovirol.. 1992. 5(11):1099-1104.

The human immunodeficiency virus establishes an intimate interaction with the immune system. The virus can use cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-I (Il-1), to regulate its own expression by modifying the normal immunoregulatory network. We demonstrate that mRNA of the cytokine TNF-alpha from peripheral blood mononuclear cells is overexpressed in virtually all patients with AIDS who do not have active opportunistic infections compared with uninfected volunteers (p < 0.0001). This overexpression correlates with elevated mRNA levels of the recently discovered GRO (p < 0.05), a cytokine involved in the inflammatory response.

Keywords: Cytokines; Tumor Necrosis Factor; Cachectin; Gro; Pentoxifylline; Melanoma Growth Stimulatory Activity (mgsa), Immunodeficiency-virus Type-1; Peripheral-blood Monocytes; Mononuclear-cells; T-cells; Expression; Cachectin; Replication; Induction; Pentoxifylline; Binding

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